Improving the Accuracy of Mesothelioma Diagnosis in China
Journal of Thoracic Oncology
Abstract: In the Western world, malignant mesothelioma (MM) is most prevalent in the pleura of older males who have been professionally exposed to asbestos. Information about MM from rapidly industrializing countries such as China is minimal.
Association of Asbestos Exposure With Malignant Mesothelioma Incidence in Eastern China
JAMA Oncology
Abstract: The reported incidence of malignant mesothelioma (MM) in China is 1.5 cases per million population, much lower than in other countries. In China, the prevalence of MM in different regions is unknown, and only 15% of MMs have been associated with asbestos exposure compared with more than 70% in most of the world.
High-density array-CGH with targeted NGS unmask multiple noncontiguous minute deletions on chromosome 3p21 in mesothelioma
Proceedings of the National Academy of Sciences of the United States of America
Abstract: We found that gene mutations/deletions are frequent in mesothelioma and occur through a variety of DNA alterations. We identified genes implicated in malignant mesothelioma: SETD2, SMARCC1, PBRM1.
Environmental risk of mesothelioma in the United States: An emerging concern-epidemiological issues
Journal of Toxicology of Environmental Health
Abstract: Despite predictions of decline in mesothelioma following the ban of asbestos in most industrial countries, the incidence is still increasing globally, particularly in women.
Malignant Mesothelioma: Time to Translate?
Trends in Cancer
Abstract: Malignant mesothelioma (MM) is an aggressive cancer largely associated with asbestos exposure. In this review, we discuss the significant advancements in our understanding of its genetics and molecular biology and their translational relevance.
Consensus Report of the 2015 Weinman International Conference on Mesothelioma
Journal of Thoracic Oncology
Abstract: On November 9 and 10, 2015, the International Conference on Mesothelioma in Populations Exposed to Naturally Occurring Asbestiform Fibers was held at the University of Hawaii Cancer Center in Honolulu, Hawaii.
Positive nuclear BAP1 immunostaining helps differentiate non-small cell lung carcinomas from malignant mesothelioma
Oncotarget
Abstract: The differential diagnosis between pleural malignant mesothelioma (MM) and lung cancer is often challenging. Immunohistochemical (IHC) stains used to distinguish these malignancies include markers that are most often positive in MM and less frequently positive in carcinomas, and vice versa.
Investigating palygorskite’s role in the development of mesothelioma in southern Nevada: Insights into fiber-induced carcinogenicity
Journal of Toxicology of Environmental Health
Abstract: Similar to asbestos fibers, non-regulated mineral fibers can cause malignant mesothelioma (MM). Recently, increased proportions of women and young individuals with MM were identified in southern Nevada, suggesting that environmental exposure to carcinogenic fibers was causing the development of MM.
BAP1 regulates IP3R3-mediated Ca2+ flux to mitochondria suppressing cell transformation
Nature
Abstract: BRCA1-associated protein 1 (BAP1) is a potent tumour suppressor gene that modulates environmental carcinogenesis1, 2, 3. All carriers of inherited heterozygous germline BAP1-inactivating mutations (BAP1+/−) developed one and often several BAP1−/− malignancies in their lifetime4, mostly malignant mesothelioma, uveal melanoma2, 5, and so on.
Germline BAP1 mutations induce a Warburg effect
Nature
Abstract: Carriers of heterozygous germline BAP1 mutations (BAP1+/−) develop cancer. We studied plasma from 16 BAP1+/− individuals from 2 families carrying different germline BAP1 mutations and 30 BAP1 wild-type (BAP1WT) controls from these same families.
